Laboratory mice Experimental evolution

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mouse garland selection experiment attached running wheel , rotation counter.


in 1998, theodore garland, jr. , colleagues started long-term experiment involves selective breeding of mice high voluntary activity levels on running wheels. experiment continues day (> 65 generations). mice 4 replicate high runner lines evolved run 3 times many running-wheel revolutions per day compared 4 unselected control lines of mice, running faster control mice rather running more minutes/day.



female mouse litter, garland selection experiment.


the hr mice exhibit elevated maximal aerobic capacity when tested on motorized treadmill. exhibit alterations in motivation , reward system of brain. pharmacological studies point alterations in dopamine function , endocannabinoid system. high runner lines have been proposed model study human attention-deficit hyperactivity disorder (adhd), , administration of ritalin reduces wheel running approximately levels of control mice. click here mouse wheel running video.








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